Impurity Identification

To obtain product registration, manufacturing impurities present at greater than 0.05% in the technical grade active substance are required to be identified and quantified as part of 5 batch studies conducted to GLP standards by accredited laboratories.

Using our expert knowledge and our analytical expertise using in-house instruments such as GC-MS LC-MS-MS, ICP, IC, HPLC and LCQToF we can deduce the correct structure of significant impurities present in samples.

We then produce reports which detail the impurity identification work.

We offer a screening service using our in-house GC-MS, LC-MS-MS and LCQToF instrumentation to enable clients to choose the best source, from a number of rival producers of technical grade pesticides, to take forward into GLP 5 batch analysis.

Our approach is based on determination of the purity of the active material, the number and identity of significant impurities, and the estimate of cost of purchase or custom synthesis of analytical standards of significant impurities.

This information enables clients to estimate the likely costs for GLP analysis of the purity / impurity profile of 5 typical production batches from competing producers, resulting in selection of the best source of the technical grade active ingredient.

Once the best source has been chosen, DNAL can start to undertake GLP 5 batch analysis on material provided by this supplier.

Stop Press

DNAL have an established track record of working with Glyphosate and challenging impurities such as NNG, Formaldehyde, AMPA and MAMPA. Currently we are able to look for more than 50 known compounds as impurities in Glyphosate. DNAL have a successfully developed a method for analysing the specified impurity Glyphosine in Glyphosate.

DNAL have previously developed methodologies for Formic Acid and Trimethylamine in Glyphosate.

DNAL have established a successful method in respect of the Mesotrione R287431 and R287432 impurities at extremely low levels.

+44 (0)1322 228 783 or email us